When a virus causes amnesia in everyone except Teyla and Ronon, the Atlantis team must work together to find a cure before their memories fade entirely.
Attack of the Show's Zach Selwyn makes a cameo appearance as a scientist in this episode, having been invited by the studio to appear after creating a rap video for the G4 cable show about wanting to be on Stargate Atlantis.
Actor D. Harlan Cutshall, who plays a Marine in this episode, played the Jaffa commander all the way back in the Stargate SG-1 third season episode "Maternal Instinct."
"We watched the Day One Mix of 'Tabula Rasa' today. Another winner! The teaser felt like something out of the movie 'Saw.' A very unique-looking episode that Marty G. predicts 'the fans are gonna love.'" (Executive producer Joseph Mallozzi, in a post at his blog)