Device designed with information obtained from the Ancient repository of knowledge, capable of rendering all Replicator elements inert. Originally developed by Jack O'Neill, it is equally capable of disabling both the mechanical and humanoid Replicator varieties.
The design for the handheld version of the device was eventually used to construct an on-board version for Asgard ships. Supreme Commander Thor's science vessel Daniel Jackson fired a prototype of the larger disruptor onto Orilla, destroying all Replicators that had remained.
New Order, Part 2 - O'Neill completes construction of a Replicator disruptor before the knowledge of the Ancients is wiped from his mind.
Gemini - Replicator Carter arrives at Earth's Alpha Site with the secret intention of studying the Replicator disruptor with the express intent of protecting herself from it.