When a research team is forced to evacuate their secret base, they find themselves on board a derelict Ancient vessel that is many galaxies away from Earth.

Stranded on the Ancient vessel Destiny, the evacuees from Icarus Base discover that a worn-out life-support system and hull breaches will suffocate them in a matter of hours.

Lt. Scott leads a team to a desert planet to locate a mineral capable of fixing Destiny's life support system. Chloe visits her mother on Earth.

The Destiny suffers a power crisis, putting the lives of the stranded crew in jeopardy when even the emergency reserves run dry. Dr. Rush pushes himself to the breaking point.

With the ship on a collision course, Young conducts a lottery to determine who will escape certain death and try and find a habitable planet with the shuttle.

Severe rationing can't save the Destiny's dwindling water supply, forcing Colonel Young and Lieutenant Scott to seek out drinkable water on a deadly ice planet.

Colonel Telford takes over Young's command in order to enact a dangerous plan to try and get the ship's crew home. Back on Earth, Young, Eli, and Chloe visit their families.

A team from Destiny arrives on a jungle planet, where they find a kino with footage of themselves they haven't shot yet.

Lt. Scott and Camille visit their loved ones using the communication stones, leading Colonel Young to a discovery about Telford's activities. On the Destiny, Rush discovers technology he believes may be able to get them home.

Colonel Young cedes command of the ship after he is implicated in the murder of a crew member.

A mishap with the communication stones sends Colonel Young's consciousness to an alien vessel, provoking the crew's first extra-terrestrial encounter.

Colonel Young's opponents launch a coup to take control of the ship, pitting the military against civilians.

The crew finds a idyllic planet when Destiny stops without its countdown clock running, tempting some crew members to stay permanently.

Rush uses the neural interface chair to try and access Destiny's systems, causing him to recall the events which led to his recruitment into the Stargate program.

A group from Destiny is left behind on a planet when the ship enters F.T.L., and must find a Stargate route back before the ship leaves the galaxy.

When problems with the F.T.L. drive threaten to leave Destiny stranded, the crew calls upon an expert from Earth to help – a quadriplegic woman who temporarily takes over Wray's body.

The ship's crew is plagued by hallucinations that manifest their fears and desires.

Dr. Rush and Homeworld Command investigate when Colonel Telford is suspected of spying for the Lucian Alliance.

The Lucian Alliance manages to board Destiny, taking several crew members hostage in a bid to wrestle control the ship.

While Colonel Young and Kiva grapple over control of the ship, a pulsar threatens everyone on board with deadly radiation.